Fitness & Nutrition News

Most people hear the words “high blood pressure” and immediately think of heart attacks. Very few stop to think about the brain. Yet doctors now say that uncontrolled hypertension may quietly damage the brain for years before a person notices anything serious.It starts subtly. Forgetting names more often. Feeling mentally slower. Struggling to focus during conversations. Misplacing things. Mood swings. These signs are easy to dismiss as stress, age, poor sleep, or burnout. But in many people, the real problem may be happening deep inside the blood vessels of the brain.High blood pressure works in a similar way. Its damage is often silent at first, but the long-term effects can stay for years.

Doctors warn that mosquito repellents alone cannot prevent dengue; eliminating stagnant water and controlling mosquito breeding are equally important. , Health, Times Now

A local general practitioner’s office said the death involved a student at Henley College. Read more at straitstimes.com.

The total global cases has been brought down to 10 from 11. Read more at straitstimes.com.

A local general practitioner’s office said the death involved a student at Henley College. Read more at straitstimes.com.

People are being warned about how this food can interact with statins

The infection passes between individuals through contact with hands, medical equipment, or surfaces contaminated with the bacteria

Exclusive: Commission says alert would trigger coordinated international response that could help avoid millions dying

As of May 15, over 600 dengue cases have been reported this year – 66 per cent less than the same period last year.

tRNA-derived fragments (tRFs) have emerged as promising non-invasive biomarkers for breast cancer. Understanding their diagnostic potential is essential for improving early detection and patient outcomes. This study aimed to investigate the expression level of the 5′-tRF-His-GTG in the blood of breast cancer patients and assess its potential as a diagnostic or prognostic biomarker. Candidate tRFs were identified through bioinformatic analyses using MINTbase, MODOMICS, and BBcancer, focusing on expression likelihood in biofluids and chemical modification profiles. A total of 56 blood samples, including 28 from breast cancer patients and 28 from healthy controls, were collected. Total RNA was extracted, and cDNA was synthesized via reverse transcription. Quantitative real-time PCR was performed to assess the expression level of tRF-32-XSXMSL73VL4YK. Statistical analysis was conducted using an independent t-test with a significance threshold of p < 0.05. tRF-32-XSXMSL73VL4YK, characterized by minimal chemical modifications, was selected for further investigation. It was significantly upregulated in breast cancer patients compared to healthy controls (p < 0.001). However, no significant associations were found between its expression and clinicopathological features such as age, tumor size, TNM stage, or IHC markers (p > 0.05). Our study identifies tRF-32-XSXMSL73VL4YK as a significantly upregulated 5’tRF-His-GTG in breast cancer, yet its expression shows no correlation with key clinical characteristics. While tRF-32-XSXMSL73VL4YK may not serve as a standalone diagnostic marker due to its lack of correlation with clinical features, its consistent upregulation suggests promise as a component of a multi-marker panel or as a prognostic biomarker.