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KAMPALA – A major health scare has erupted after people living with HIV claimed they...
When Ebola outbreaks occur, public attention often focuses on vaccines, treatments, and healthcare workers on the front lines. However, controlling the spread of the disease depends on more than medical innovation. Effective outbreak response requires strong logistics systems that can quickly deliver information, supplies, and healthcare resources to communities in need. Medical advances are only
Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover. Thirty-four distinct cell types were identified, and disease-relevant cells prioritized using enrichment for rare skeletal disorder genes and bone-mineral-density-associated genes in an extended UK Biobank genome-wide association study. Functional validation was undertaken in over 1,000 genetically modified mouse models. Endothelial cells and vascular smooth muscle cells were identified as new skeletal-disease-relevant cells alongside osteoblast, chondrocyte and osteoclast cell lineages. Hundreds of cell-specific genes with unappreciated roles in skeletal pathophysiology were identified. This comprehensive cellular and molecular framework underpins skeletal physiology and disease and will help prioritize new therapeutic targets to accelerate development of therapies to treat musculoskeletal disease. The study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcriptional programs.
For years, exercise has always been associated with losing weight or achieving a more attractive physique. Today, health experts
BUNIA, July 10 (Reuters) – Four out of every five new Ebola cases in parts of Democratic Republic of Congo have no known link to existing patients, a senior World Health Organization official said, warning that the true scale of the outbreak could be two to four times larger than official data suggest. The figures underscore the […]
Fibroids remains one of the most common health conditions affecting women, yet many continue to suffer in silence due to delayed diagnosis, limited awareness and misconceptions surrounding treatment.
Cannabis, commonly known as marijuana, is a plant that contains psychoactive compounds that can temporarily alter people's brain activity and perceptions. While the consumption of this plant for medical or recreational purposes is now legal in a number of regions worldwide, past studies have linked its frequent use to a higher risk of psychosis.
New research, led by scientists from the Seaver Autism Center for Research and Treatment at Mount Sinai and published in Autism Research, has estimated that Phelan-McDermid syndrome (PMS) affects approximately 1 in 7,300 people, making it far more common than previous estimates suggested.
As genomics infrastructure expands, current governance will determine whether it advances global health equity or entrenches disparities, locking biased data into future clinical tools. This Comment calls for inclusive, community-centered genomic systems, before biased data and extractive models becoming the default.
The Democratic Republic of Congo faces an escalating Ebola outbreak, with new cases significantly exceeding existing patient links. A WHO official warns the situation may be far worse than reported, highlighting intense community transmission and the urgent need for improved surveillance and health worker training.