Fitness & Nutrition News

SINGAPORE – A Singapore Airlines (SIA) passenger infected with measles who travelled through Singapore’s Changi Airport is not linked to any other known cases here, said the Communicable Diseases Agen...

Deep mutational scanning (DMS) can define functional constraints acting on viral proteomes by quantifying the effects of mutations on viral fitness. However, DMS analyses do not discern type-specific from species-level constraints, limiting their utility in understanding how selective pressures change as viral families diversify. Here we show that comparison of DMS datasets from related viruses can overcome these limitations. By contrasting two proteome-wide DMS datasets from prototypical members of the enterovirus A and B species, we identify evolutionary constraints at the species level to occur across core enzymatic machinery and capsid assembly interfaces. In contrast, type-level constraints are observed across host-interaction sites in both structural and non-structural proteins. Furthermore, we find DMS data to reflect both type- and species-level evolutionary signatures in nature yet diverge at conserved hotspots subjected to selection pressures that are lacking in vitro. Finally, we highlight the utility of comparative DMS studies for drug discovery by identifying a mutationally constrained pocket in the 2C helicase that is conserved across all major human enterovirus species. Our findings provide a framework for dissecting evolutionary pressures acting at different evolutionary scales and for guiding the rational design of broad-spectrum therapeutics with high barriers to resistance. A comparison of proteome-wide mutational scanning datasets from enterovirus A and B species reveals evolutionary constraints shared by these viral species that localize to core functional regions, as well as species- and type-specific constraints that map to distinct host interactions.

Bigg Boss OTT 3 winner Sana Makbul has transitioned to a vegan diet to manage autoimmune hepatitis, a chronic condition she has been battling since 2020 that sometimes presents symptoms of Lupus or Arthritis. Gastroenterologist Dr. Manish Dodmani explains that for autoimmune liver patients, a plant-based diet can reduce inflammation and ease the liver's workload by eliminating heavy saturated fats, provided the transition is medically supervised to avoid nutrient deficiencies in B12, iron, and protein. While Sana successfully navigated the high-stress environment of reality TV by coordinating between her doctors and show producers, experts emphasize that while a "cleaner" vegan diet supports organ function and energy levels, it serves as a supportive lifestyle choice rather than a replacement for long-term medical treatment.

Nestlé has published new clinical research indicating that certain NAD+ precursors can boost cellular energy levels and influence gut microbiome activity.

Research Highlights: Although women typically have less artery-clogging plaque than men, a study of more than 4,200 adults found that it did not

Metastatic ILC shows significant biomarker heterogeneity, limiting single biopsy reliability and highlighting challenges in detection and monitoring.

Measles and rubella surveillance data and analyses are updated daily and reported weekly. The reported figures may be influenced by the number of specimens from suspected cases that are received by the laboratory at the time of testing. Measles surveillance The national measles surveillance has detected an increase in measles cases countrywide. Data available (accessed […]

Research Highlights:Although women typically have less artery-clogging plaque than men, a study of more than 4,200 adults found that it did not shield

Heart failure patients often fear exercise, but doctors say safe, supervised physical activity improves circulation, strength, and quality of life. Walking, cycling, swimming, and light strength training are recommended, while high-intensity workouts and heavy lifting should be avoided. Always consult a cardiologist and stop if severe symptoms appear. , Health, Times Now

Researchers show STING pathway activation shrinks meningioma tumors by promoting necrosis, immune responses, and extracellular matrix degradation.